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We can think of a few ways to get the hair gel out of your hair. Say a burst of calcium ions is released in the cell in response to a biological signal and the ions bind to calcium-receptor proteins. Eventually, almost all the proteins will lose their calcium ions as the signal is removed — from John Travolta to nerd.{/INSERTKEYS}{/PARAGRAPH} Recall our observation about putting in hair gel: some of it stays on your hands, in an effective equilibrium with the gel in your hair. But you can get out that excess gel and avoid bumps and splashing by thinking statistically. Allow ligands to interact with proteins and they will reach a binding equilibrium. You get some gel, smear it around on your hands, and then give yourself a head massage with those gelly hands. Time to get rid of some of that gel. For those of you in the business, the analogy to protein-ligand binding is obvious. So you can use the principle underlying that observation to remove gel. Your hair is like a set of proteins and the gel represents ligands ions, small molecules or other proteins. Wash it off and repeat til you transform yourself back to a respectable nerd. One is to take a shower. Some of the gel is on your hands. {PARAGRAPH}{INSERTKEYS}We want to consider two tasks: putting hair gel in and taking it out. But we can stretch the analogy a step further to invoke signaling in the cell. Better smear it around your hands first, for quicker homogenous application. Put your clean maybe wet hands in your hair and rub them around to establish an equilibrium. In essence, you have established an equilibrium between the gel in your hair and the gel on your hands. OK, now wash your hands, and keep reading.